High end - arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia 1 and gestational hypertension at high altitude

نویسندگان

  • Vaughn A. Browne
  • Lilian Toledo-Jaldin
  • R. Daniela Davila
  • Luis P. Lopez
  • Henry Yamashiro
  • Darleen Cioffi-Ragan
  • Colleen G. Julian
  • Megan J. Wilson
  • Abigail W. Bigham
  • Mark D. Shriver
  • Benjamin Honigman
  • Enrique Vargas
  • Robert Roach
  • Lorna G. Moore
چکیده

AFFILIATIONS: Altitude Research Center, Dept. of Emergency Medicine, Dept. of OB/Gyn, and Dept. of 6 Health/Behavioral Sciences, University of Colorado Denver, Denver, CO; Instituto Boliviano de Biología de 7 Altura, La Paz, Bolivia, Graduate School of Arts and Sciences, Wake Forest University, Winston-Salem, NC. 8 Anthroplogical Genetics Laboratory, Pennsylvania State University, State College, PA 9

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High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude.

The reduction in infant birth weight and increased frequency of preeclampsia (PE) in high-altitude residents have been attributed to greater placental hypoxia, smaller uterine artery (UA) diameter, and lower UA blood flow (Q(UA)). This cross-sectional case-control study determined UA, common iliac (CI), and external iliac (EI) arterial blood flow in Andeans residing at 3,600-4,100 m, who were e...

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Uterine artery blood flow, fetal hypoxia and fetal growth.

Evolutionary trade-offs required for bipedalism and brain expansion influence the pregnancy rise in uterine artery (UtA) blood flow and, in turn, reproductive success. We consider the importance of UtA blood flow by reviewing its determinants and presenting data from 191 normotensive (normal, n = 125) or hypertensive (preeclampsia (PE) or gestational hypertension (GH), n = 29) Andean residents ...

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Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model.

Preeclampsia and fetal growth restriction are responsible for the majority of maternal and perinatal morbidity and mortality associated with complicated pregnancies. Although their etiologies are complex and multifactorial, both are associated with increased uterine artery resistance. Sildenafil citrate is able to rescue the dysfunction observed ex vivo in uterine arteries of women with preecla...

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Doppler ultrasound screening predicts recurrence of poor pregnancy outcome in subsequent pregnancies, but not the recurrence of PIH or preeclampsia.

OBJECTIVE To assess the role of Doppler uterine artery screening in the prediction of recurring hypertensive disorders in a high-risk population. METHODS Ninety-four women with a history of hypertensive disorders in previous pregnancies underwent ultrasound color Doppler to analyze blood flow in the uterine arteries at 21-22 weeks of gestation. We evaluated the performance of the Pulsatility ...

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تاریخ انتشار 2011